Laryngeal Oedema/ Spasm

Important Causes : Anaphylaxis, Anaphylactoid reaction, Infection (erysipelas)
C1 Inhibitor Def., Drug Hypersensitivity

Differentiation is by symptoms and investigation.
Anaphylaxis is associated with bronchial spasm and hypotension and is due to IgE triggered mast cell degranulation while anaphylactoid is associated with Non IgE triggered Mast Cell Degranulation.
C1 inhibitor def does not cause urticaria while above two causes usually do.also it doesnt responce to epinephrine.

Imp: Dont forget C1 inhibitor def, drug history, resuscitation, allergy test and epinephrine self administration teaching.